alpha-Mannosidase

An enzyme that catalyzes the HYDROLYSIS of terminal, non-reducing alpha-D-mannose residues in alpha-D-mannosides. The enzyme plays a role in the processing of newly formed N-glycans and in degradation of mature GLYCOPROTEINS. There are multiple isoforms of alpha-mannosidase, each having its own specific cellular location and pH optimum. Defects in the lysosomal form of the enzyme results in a buildup of mannoside intermediate metabolites and the disease ALPHA-MANNOSIDOSIS.

Also Known As:

LAMAN; alpha-D-Mannosidase; Neutral alpha-Mannosidase; alpha Mannosidase B; alpha-D-Mannoside Mannohydrolase; Lysosomal alpha Mannosidase; Mannohydrolase, alpha-D-Mannoside; Mannosidase B, alpha; Neutral alpha Mannosidase; alpha D Mannosidase; alpha D Mannoside Mannohydrolase; alpha Mannosidase; alpha-Mannosidase, Lysosomal; alpha-Mannosidase, Neutral; Lysosomal alpha-Mannosidase

Enzymes and Coenzymes: 1
- Enzymes: 152586
  - Hydrolases: 2166
    - Glycoside Hydrolases: 871
      - Mannosidases: 150
        alpha-Mannosidase: 293

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Disease

Drug/Important Bio-Agent (IBA)